NEET Biology: Disorders of muscular and skeletal system-Gout Practice Questions
15 free multiple-choice questions on Disorders of muscular and skeletal system-Gout (Locomotion and Movement) for NEET Biology, each with the correct answer and a step-by-step explanation. Attempt a question, then reveal the solution to check your reasoning.
Practice thousands more NEET questions in the app →Q1. Gout, a form of inflammatory arthritis, primarily causes painful swelling and inflammation in which of the following joints?
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Correct answer: D — Ankle
Gout typically presents as acute arthritis, most commonly affecting the first metatarsophalangeal joint of the big toe (podagra).
Q2. Which of these is a common risk factor for developing gout?
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Correct answer: D — High intake of red meat and alcohol
High intake of purine-rich foods (like red meat) and alcohol consumption are well-known risk factors for hyperuricemia and gout development.
Q3. Which of the following is considered a major risk factor associated with the development of hyperuricemia, a precursor to gout?
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Correct answer: D — High consumption of purine-rich foods
Hyperuricemia is linked to increased purine metabolism. High intake of purine-rich foods (like red meat and seafood) leads to increased uric acid production.
Q4. Which substance accumulates in the blood and joints, leading to the formation of uric acid crystals that cause gout?
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Correct answer: D — Uric acid
Gout is caused by hyperuricemia, an elevated level of uric acid in the blood, which leads to the crystallization of uric acid in the joints, causing inflammation.
Q5. What is the primary goal of managing the condition of gout in a patient?
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Correct answer: D — To reduce uric acid levels and control inflammation
The main therapeutic goal is to manage the hyperuricemia by lowering uric acid levels and controlling the resulting severe inflammatory attacks.
Q6. In the context of musculoskeletal disorders, gout primarily targets which type of joint structure?
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Correct answer: B — Synovial joints
Gout classically attacks the synovial joints, which are characterized by a joint capsule lined with synovial membrane, making them highly susceptible to crystalline deposition.
Q7. Which component of the skeletal system is directly affected by the presence of uric acid deposits in gout?
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Correct answer: B — The bone itself
While the joint is affected, the deposition often involves the bone structure and the surrounding tissues. Uric acid crystals directly affect the tissues surrounding the bone, leading to bone and joint pathology.
Q8. The acute phase of a gout attack is primarily characterized by intense pain, swelling, and redness. This inflammation is caused by the release of which substance?
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Correct answer: C — Prostaglandins
The intense inflammatory response observed during an acute gout flare is mediated by the release of inflammatory mediators, primarily prostaglandins, which sensitize the nerve endings.
Q9. Gout is classified as a form of inflammatory arthritis. What is the specific tissue that becomes intensely inflamed due to uric acid crystal deposition in gout?
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Correct answer: D — Synovial membrane
The synovial membrane lines the joint cavities. The deposition of uric acid crystals in the synovial fluid and membrane causes acute inflammation, which is the hallmark of gout.
Q10. Which of the following joints is most commonly affected by gout attacks?
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Correct answer: A — Big toe (MTP joint)
The first metatarsophalangeal (MTP) joint of the big toe is the most frequent site for acute gout attacks.
Q11. The crystals that form in the affected tissues during a gout attack are composed primarily of which compound?
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Correct answer: C — Uric acid
The defining pathological feature of gout is the formation of sharp, needle-shaped crystals of monosodium urate (uric acid).
Q12. Gout is fundamentally a form of arthritis caused by the deposition of uric acid crystals. In which anatomical structures is this deposition most commonly observed leading to pain and swelling?
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Correct answer: B — Synovial joints
Gout is an inflammatory arthritis caused by uric acid crystal deposition, most commonly affecting the joints, particularly the synovial joints, leading to characteristic pain and swelling.
Q13. The formation of gout crystals within the joint space leads to which physiological consequence?
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Correct answer: B — Release of inflammatory mediators
The deposition of monosodium urate crystals causes severe local inflammation, pain, and swelling within the joint space.
Q14. Which systemic imbalance is the underlying metabolic condition that predisposes an individual to developing gout?
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Correct answer: C — Hyperuricemia
Gout is a manifestation of hyperuricemia, which means an abnormally high level of uric acid in the blood, causing potential crystal formation.
Q15. The acute attack of gout most commonly affects which specific joint in the foot?
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Correct answer: B — Metatarsophalangeal joint of the big toe (Podagra)
The most frequent site for acute gout attacks is the first metatarsophalangeal joint of the big toe, known as Podagra.
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