JEE Main Chemistry: Drug-target interaction Practice Questions
15 free multiple-choice questions on Drug-target interaction (Chemistry in Everyday Life) for JEE Main Chemistry, each with the correct answer and a step-by-step explanation. Attempt a question, then reveal the solution to check your reasoning.
Practice thousands more JEE Main questions in the app →Q1. The interaction between a drug molecule and its biological target (like a receptor) is primarily governed by which principle?
Show answer & explanation
Correct answer: C — Molecular fit and binding affinity
Drug-target interaction is fundamentally based on the physical fit (molecular shape complementarity) and the strength of the forces (binding affinity) between the drug and the target site.
Q2. The biological system or macromolecule that acts as the molecular target for a drug is typically classified as a:
Show answer & explanation
Correct answer: B — Receptor
Receptors (like G-protein coupled receptors or enzyme active sites) are the common targets for most therapeutic drugs.
Q3. The ability of a drug to bind selectively to its intended target over other similar targets is referred to as:
Show answer & explanation
Correct answer: D — Selectivity
Selectivity refers to the drug's preference for binding to one specific target over others, which is crucial for minimizing side effects.
Q4. Which term describes the strength of the non-covalent interaction between a drug molecule and its biological target (receptor or enzyme)?
Show answer & explanation
Correct answer: A — Receptor Affinity
Receptor affinity is the measure of the strength of the binding interaction between a drug and its target molecule.
Q5. Which property describes the strength of the interaction between a drug molecule and its biological target (e.g., receptor or enzyme)?
Show answer & explanation
Correct answer: A — Binding affinity
Binding affinity measures the strength of the non-covalent interaction between the drug and its target molecule.
Q6. The site on a protein where a drug binds and exerts its pharmacological effect is known as the:
Show answer & explanation
Correct answer: C — Active site
The binding pocket (or site) is the specific location on the protein where the drug molecule physically binds.
Q7. A drug that binds to a receptor but does not activate it, thus blocking the action of endogenous ligands, is called a(n):
Show answer & explanation
Correct answer: C — Antagonist
An antagonist binds to the receptor but prevents the natural binding of the agonist, thereby blocking the receptor's response.
Q8. A drug that binds to a receptor and activates it to produce a biological response is known as a(n):
Show answer & explanation
Correct answer: C — Agonist
An agonist is a substance that binds to a receptor and activates it, leading to a biological effect.
Q9. Selectivity in drug design primarily refers to the drug's ability to interact with:
Show answer & explanation
Correct answer: B — A single target only
Selectivity refers to the ability of a drug to bind to one specific target receptor while minimizing binding to other unintended targets.
Q10. A drug that binds to a receptor site and prevents the action of an endogenous ligand is classified as a:
Show answer & explanation
Correct answer: B — Antagonist
An antagonist binds to the receptor but does not activate it, thereby blocking the action of the natural signaling molecule.
Q11. What is the primary goal of a drug when interacting with a biological target receptor?
Show answer & explanation
Correct answer: C — To block the natural activity of the receptor
Most therapeutic drugs aim to modulate (change or block) the natural activity of the target receptor to achieve a therapeutic effect.
Q12. If a drug binds to a receptor site, the phenomenon where the drug binds to a site other than the primary active site is known as:
Show answer & explanation
Correct answer: C — Allosteric binding
Allosteric binding involves binding at a site distinct from the primary binding site, which modulates the activity of the target.
Q13. In a competitive binding scenario, if an antagonist is introduced, it competes directly with the agonist for binding to the same site. This competition is primarily based on:
Show answer & explanation
Correct answer: D — Relative binding affinity
In competitive binding, the ability of the antagonist to bind effectively is determined by its relative affinity compared to the agonist for that specific target site.
Q14. Which type of binding mechanism is generally considered reversible in the context of drug-receptor interactions?
Show answer & explanation
Correct answer: D — Reversible binding
Reversible binding implies that the drug-target complex dissociates naturally, which is characteristic of most physiological drug interactions.
Q15. Which term describes the measure of the strength of the interaction between a drug molecule and its biological target?
Show answer & explanation
Correct answer: C — Affinity
Affinity describes the strength of the non-covalent bond formed between the drug and the target; higher affinity means a stronger interaction.
Keep going — practice on Padhai Karlo
Padhai Karlo gives you unlimited JEE Main practice: chapter-wise questions, timed quizzes, and full mock tests with an All-India Rank — free to start.
Get the free Android app →